Objective To explore the influencing factors of skeletal muscle wasting among stable COPD Patients. Methods A total of 141 regular clinic-visiting patients with stable COPD were recruited by convenience sampling method and evaluated, with the general questionnaire, comprehensive evaluation indicators, bioelectrical impedance analysis（BIA）, and the COPD Quality of Life（QOL） Questionnaire. Results The average of fat free mass index was（17.19±1.94）kg/m2 through BIA. The incidence rate of skeletal muscle wasting was 31.20%（44 cases）.There were significant differences in scores of QOL, ADL, and anxiety between the skeletal muscle wasting and non-wasting groups （P＜0.05，P＜0.01）. Logistic regression analysis revealed that BMI, FEV1% and dyspnea scores were the factors affecting skeletal muscle was-ting （P＜0.05，P＜0.01）. Conclusion Skeletal muscle wasting, which is associated with low body mass, severe airflow restriction, and dyspnea, is serious in stable COPD patients, and it affects the quality of life of patients.