Objective To establish and evaluate the effect of nurse-led multidisciplinary management program for patients with dysphagia. Methods A dysphagia management team was formed by the department of nursing, and 4 working groups of education/training, specification/instruction development, quality control, and research/evidence were set up. Responsibilities of the 4 working groups were formulated, standardized training and management were provided for 46 liaison nurses, and dysphagia screening, patient referral process, as well as multidisciplinary collaboration model were developed and implemented in practice. Results Dysphagia related knowledge and skills of the liaison nurses, as well as accurate screening rate were significantly improved after 3 months of the intervention (P<0.01 for all). The incidence rate of pneumonia in pilot departments were significantly decreased (P<0.01). Conclusion Implementation of scientific and standardized training, hierarchical management of dysphagia, three-level quality control mechanism, and multidisciplinary collaboration in clinical practice, can enhance dysphagia related knowledge and skill of nurses, resulting in improving outcome of patient.