Objective To understand the current status of medication adherence and its influencing factors in male gout patients at home. Methods A total of 425 gout patients were investigated using general information questionnaire, the Gout Impact Scale and the Morisky Medication Adherence Scale. Results The gout patients′ score of medication adherence was （4.87±2.22）, and the score of gout impact was （60.08±15.77）. Except the dimension of concern to activity during attack, there were significant and negative correlations between the total score and each dimension scores of gout impact and the total score of medication adherence （P＜0.05,P＜0.01）. Multiple stepwise regression analysis showed that, serum uric acid concentration, duration of disease, side effects of gout medications and unmet gout treatment needs were the main factors influencing the medication adherence of male gout patients at home （P＜0.05,P＜0.01）. Conclusion The medication adherence of male gout patients at home is low, and the gout impact is the main influencing factor. It is necessary to strengthen the health education on the characteristics of the disease and the significance of medication treatment for patients, and to raise patients′ awareness and attention of medication treatment, so as to improve their medication adherence.