Objective To explore the effects of multi-mode continuing care on anxiety, postoperative complications and quality of life in prostate cancer patients undergoing radical prostatectomy. Methods Totally 112 prostate cancer patients undergoing radical prostatectomy were randomized into an experimental group and a control group, with 56 cases in each group.The control group was given routine nursing and discharge guidance, while the experimental group additionally received multi-mode continuing care.The degree of anxiety and quality of life of the two groups were assessed at different time points before and after disacharge, and the improvement of incontinence was calculated. Results At 1, 3 and 6 months after discharge, the degree of anxiety in the experimental group were significantly milder than those in the control group, and at 6 months after discharge, the SF-36 score and the improvement of postoperative incontinence were significantly better than those in the control group （P＜0.05,P＜0.01）. Conclusion The implementation of multi-mode continuing care for prostate cancer patients undergoing radical prostatectomy after discharge can significantly relieve their anxiety, enhance their recovery and their quality of life.