Objective To explore the teaching effect of Wechat combining with scene simulation in the course of Effective Communication. Methods Thirty-seven undergraduate nursing students enrolled in 2016 were regarded as a control group, who received scene simulation teaching in the course of Effective Communication；and 38 students enrolled in 2017 were taken as a study group, who were taught using Wechat combining with scene simulation teaching in the course. Results At the end of the course teaching, the communication ability score of the study group and control group was 86.66±8.29 and 69.35±8.98, there was significant difference (P＜0.01）. The final examination score of the study group was significantly higher than that of the control group, and the course teaching effect evaluation of the students from the study group was significantly better than that of the control group （P＜0.05，P＜0.01）. Conclusion Combination of on-line Wechat and off-line scene simulation teaching is conducive to increasing the course teaching effect of Effective Communication,and improving nursing students′ communication ability.