Objective To investigate therapy-related symptoms among lung cancer patients, and analyze its influencing factors, so as to provide reference for symptom management. Methods Totally 302 lung cancer patients were investigated using Karnofsky performance score, Therapy-related Symptom Checklist （TRSC） and Brief COPE Inventory （BCI）. Results The total TRSC score among lung cancer patients was （20.62±9.10）, which was （14.73±8.13） for the patients undergoing radiotherapy, （19.12±7.95）for the patients suffering chemotherapy, and （23.45±9.02） for the other patients experiencing combined chemoradiotherapy. The result of regression analysis indicated that, treatment regimen, cancer TNM stage, and the coping style of refusal, planning, positive coping and using useful support were main influencing factors of therapy-related symptoms among lung cancer patients, which totally explained 33.70% variance of TRSC score. Conclusion Lung cancer patients suffer serious therapy-related symptom distress, and the patients undergoing combined chemoradiotherapy or only chemotherapy, with advanced stage Ⅳcancer and using refusal coping style are prone to encounter more serious symptoms. Medical staff should guide cancer patients to apply positive coping styles to relieve therapy-related symptoms.