Objective To evaluate the effect of three-dimensional intervention on wandering behaviors during hospitalization of patients with mild Alzheimer′s disease. Methods Totally, 60 patients with mild Alzheimer′s disease were sequentially divided into 2 groups, with 30 cases in each group. The control group was given conventional nursing care, while the intervention group was given three-dimensional intervention: interventional strategies were sought from the perspectives of adjusting risk factors, alleviating current symptoms, and improving quality of life. The before- after differences of wandering behaviors, quality of life between the two groups were compared by using the Algase Ranking Scale （RAWS）and the Dementia- Quality of Life Scale （DQOL）, and the incidence rates of adverse events related to wandering behaviors were compared, too. Results The intervention group had higher total and dimension scores of RAWS and DQOL than the control group after intervention, and lower incidence rate of adverse events related to wandering behaviors （P＜0.05,P＜0.01）. Conclusion Three-dimensional intervention during hospitalization can reduce wandering behaviors, decrease the incidence rate of adverse events, and improve the quality of life of patients with mild Alzheimer′s disease.