Objective To explore the construction and application of the APS standardized practice system for patient falls prevention. Methods With the goal of "reducing falls", we constructed an APS (Assessment, Platform, Supervision) standardized practice system for preventing patient falls from the aspects of organizational management, evaluation and implementation of measures, quality control, and information construction. Then we conducted a comparative study to check on the effects of the system. Results After the implementation of the APS standardized practice system for patient falls prevention, the incidence rate of falls was lower than before; the accuracy, timeliness of nurses′ fall risk assessment, and implementation rate of nursing measures were higher than before （P＜0.01 for all）. Conclusion The construction of the APS standardized practice system for patient falls prevention can reduce the incidence of falls, improve patient safety during hospitalization, and nurses′ability to manage the risk of falls.As a result, the quality of care is improved.