Objective To investigate the effect of multidisciplinary nutrition management on head and neck cancer patients receiving radiotherapy. Methods Totally, 88 head and neck cancer patients receiving radiotherapy were recruited, and assigned to receive either routine nutritional guidance (the control group,n=42) or multidisciplinary nutrition management, starting from 1 week before radiotherapy to the end of the therapy (the intervention group,n=46).The patients were followed up every 2 weeks during radiotherapy.The changes of indexes （amounts of 24-hour energy and protein intake, 1-month weight loss percentages and PG-SGA scores） were measured and compared between the two groups at four different stages of radiotherapy, including the initiation, the 2nd week, the 4th week, and the end of radiotherapy. Results There were significant group effect, time effect and group by time effect in all the above-mentioned indexes between the 2 groups （P＜0.01 for all）. Conclusion Application of multidisciplinary nutrition management to head and neck cancer patients receiving radiotherapy could result in an increased 24-hour energy and protein intake, a decrease in weight loss and better nutrition status for patients.