Objective To explore the effect of dignity therapy on patients with mild cognitive impairment(MCI). Methods By conve-nience sampling method, 92 MCI patients were selected and evenly randomized into 2 groups :the control group received routine care, while the intervention group received dignity therapy.Patients were measured with the Patient Dignity Inventory (PDI), the Hospital Anxiety and Depression Scale (HADS), and the Montreal-Cognitive Assessment (MoCA) scale at baseline, and 2 weeks into the intervention. Results After the intervention, the intervention group had higher dignity and cognitive scores, and lower an-xiety and depression scores, than the controls (P＜0.05，P＜0.01). Conclusion Dignity therapy could reduce the degree of dignity damage, anxiety and depression levels in MCI patients, and improve their cognitive function.