Objective To understand frailty level in hemodialysis population and to provide evidence for anti-frailty intervention for dialysis patients. Methods A total of 201 patients on regular hemodialysis therapy in 7 general hospitals′ dialysis centers in Zigong city were selected as convenient samples. The FRAIL Scale was used to evaluate the frailty condition of hemodialysis patients, and a self-designed demographic data questionnaire and a frailty factors questionnaire were used to collect relevant data. Results The median frailty score of the respondents was 2(1,4) points, with 44.8% deemed to be frail, 37.8% pre-frail, and 17.4% non-frail. There were significant differences in patients′ frailty scores by numbers of oral medicine, frequencies of hemodialysis therapy, and malnutrition risks （P＜0.05,P＜0.01）; there were also significant differences in ages, ADL scores, C-reactive protein (CRP), and albumin levels among the frail, pre-frail, and non-frail groups （P＜0.05,P＜0.01）.Logistic analysis showed that, malnutrition risks, genders, ADL scores, and albumin levels were influencing factors of frailty （P＜0.05,P＜0.01）. Conclusion Occurrence of frailty is high in hemodialysis patients. Female patients, those who have low level of serum albumin, those having poorer ADL scores, and those at risk of malnutrition, were more prone to frailty. Measures should be taken to prevent frailty, slow down the progress of frailty, and the occurrence of adverse clinical events.