Objective To identify the status and barriers of continuity of care for maintaining the patency of PICC from patient′s and community health care center′s perspectives, and to provide reference for popularizing continuity of care for PICC maintenance in community health care centers. Methods A total of 196 patients who received PICC maintenance in 3 tertiary hospitals were surveyed using a selfdesigned questionnaire, and 10 managers of community health care centers were invited to participate in semistructured interviews. Results Nearly ninety percent (88.8%) of the patients received PICC maintenance in tertiary hospitals, 31.1% of them were willing to receive PICC maintenance in community health care centers, but 61.2% of them would not go to community health care center for PICC maintenance because of inadequate skill of community health professionals. Through the semistructured interviews, 6 themes were identified: deficiency of community health professionals, inadequate knowledge and skills, worry of risk, lack of legal document for charge, lack of national support policy, and advice of increasing medical risk insurance. Conclusion PICC maintenance in community health care center is not satisfactory and is hinderd by several barriers, so the government, tertiary hospital and community health center should actively take measures to solve the problem, thus to encourage and support the community health care center′s role of primary health protection.