Objective To evaluate the effect of comfort and patientcentred care without excessive sedation (eCASH) concept combined with early mobilization in the critically ill receiving mechanical ventilation in ICU. Methods Ninetysix critically ill patients with mechanical ventilation were assigned into two groups chronologically, with 48 in each. The control group was given routine analgesia and sedation, as well as routine nursing care, while the observation group received eCASH concept based nursing care and early mobilization strategies. Results The observation group had lower incidence of delirium and ICU acquired weakness, higher Medical Research Council (MRC) score, and shorter mechanical ventilation and ICU stay compared with the control group （P＜0.05, P＜0.01 ）. Conclusion Application of eCASH concept combined with early mobilization strategies in patients with mechanical ventilation can effectively reduce delirium and ICU acquired weakness, shorten mechanical ventilation and ICU stay, and contribute to recovery of patient.