Objective To implement measures for maintaining gastrointestinal function during enhanced recovery after surgery (ERAS) program on patients undergoing resection of hepatocellular carcinoma (HCC) and to evaluate the application effects. Methods Seventyeight patients with HCC undergoing liver resection were assigned into two groups chronologically. The control group of 40 patients received routine perioperative care, while the intervention group of 38 patients were subjected to an ERAS program, in which wholecourse measures regarding gastrointestinal function were implemented, including nutritional screening and intervention after admission, intake of carbohydrates before surgery, oral dietary intake and nutritional support after surgery as early as possible, early mobilization, gum chewing, massage of the Zusanli acupuncture point, and fomentation with fennel on the abdomen. Results The intervention group had lower incidence rates of thirst and hungry, earlier outofbed mobilization and recovery of gastrointestinal function, higher albumin and prealbumin levels, and less ascites and infection compared with the control group (P<0.05, P<0.01）. Conclusion The above measures implemented in ERAS program were safe and effective for patients undergoing liver resection for HCC, because it allowed maintaining of gastrointestinal function and promoted faster postoperative recovery.