Objective To investigate the risk factors of hematologic malignancies patients developing infection in granulocyte deficiency period of chemotherapy, to form a corrected MEWS score suitable for early warning of indection in hematological malignancies patients, and to achieve better early warning results. Methods A retrospective study was conducted to collect data of 179 patients who met the inclusion criteria.Multivariate logistic regression analysis was used to identify the independent risk factors which affected the prognosis of patients, and a corrected MEWS score was formed.According to the patient′s prognosis and whether to implement emergency treatment, the predictive efficacy of the two MEWS scores was compared, and the discrimination and the best cut-off points were evaluated. Results Multiple organ dysfunction syndrome （MODS）, electrolyte imbalance, and changes in respi-ratory rate, SaPO2, and consciousness were independent risk factors for prognosis. The scores of the two instruments in the death group and the emergency treatment group were higher than those in the survival group and non-emergency treatment group （P＜0.01 for both）. The two instruments had moderate predictive value in the prognostic discrimination, and the predicted value of the corrected MEWS score （AUROC=0.898） was significantly higher than the MEWS score （AUROC=0.810）, the best cutoff points being 8.5 and 4.5 respectively. In predicting the implementation of emergency response, the corrected MEWS score had medium predictive value （AUROC=0.730）, and the optimal cut-off point was 5.5 points, versus lower predictive value（AUROC=0.692） and 4.5 points by MEWS score. Conclusion The corrected MEWS score had a moderate predictive value in prognostic discrimination and emergency implementation, which would be more suitable for the evaluation of hematologic malignancies patients developing infection in granulocyte deficiency period.