Objective To explore the level of psychological empowerment and professional burnout among obstetric nurses in Guangdong province under two-child policy, to probe into the relationship between the two variables, and to provide theoretical references to ease obstetric nurses′ job burnout. Methods A general information questionnaire, the Psychological Empowerment Scale and Maslach Burnout Inventory (MBI) were used to survey 1154 obstetric nurses in Guangdong province. Results Obstetric nurses scored (45.23±6.73) points in psychological empowerment, which was at the medium level； they scored (28.08±12.42)points in emotional exhaustion, (9.24±7.47)points in depersonalization, and (34.78±8.13)points in personal accomplishment.Obstetric nurses′ psychological empowerment was negatively correlated with emotional exhaustion （r=-0.357,P＜0.01） and deperso-nalization （r=-0.304,P＜0.01）, while positively correlated with personal accomplishment （r=0.458,P＜0.01）. Conclusion Obstetric nurses′ psychological empowerment was at medium level, and they experienced moderate to high level of job burnout.Psychological empowerment was negatively correlated with levels of job burnout.Nursing managers can reduce job burnout levels by improving psychological empowerment level of obstetric nurses,in an effort to suit the context of mounting obstetric workload under two-child policy.