Objective To develop a conceptual model of evidence implementation in nursing practice in China. Methods A grounded theory study using unstructured in-depth individual interviews was conducted with 56 participants involved in 24 evidence-based nursing implementation projects in Mainland China. Projects related documents were also collected. Transcribed data were analyzed first by initial coding, and then focal coding with constant comparison was processed. Results A model with the core "taking root" was developed to describe evidence implementation in nursing practice in China.This model included three components, including the evidence implementation process, influencing factors and Chinese nursing managers′ leadership practice to promote evidence implementation. Conclusion evidence implementation is a sustaining cycle of 4 stages.The influencing factors requires persistent evaluation, and the role of nursing managers should be prized.Involvement of various levels of the healthcare workers in evidence implementation process should be encouraged. With the help of a supportive system, and targeted strategies, the concept of evidence-based nursing and evidence itself will be able to effectively and sustainably "take root" in the system, in daily caring work, as well as in nurses′ professional development.