Objective To explore the effect of spouse intervention on treatment of male erectile dysfunction. Methods Totally, 158 erectile dysfunction patients, admitted from June 2015 through October 2017, were randomly divided into 2 groups.The control group was given drug treatment and psychological therapy .For the observation group,beside drug treatment and psychological intervention,their spouse were designed to participate in the treatment according to established experimental scheme at the same time.Before and after treatment, the erectile function domain of the International Index of Erectile Function (IIEF), the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS), the Self-esteem and Sexual Relationship Questionnaire were used mea-sure the 2 groups. Results Before treatment, there was no significant differences regarding erectile function, treatment satisfaction, and self-esteem, overall relationship satisfaction and sexual relationship satisfaction scores between the two groups （P＞0.05 for all）; after treatment, the patients scored higher in the indexes, with the observation group achieving better results than the controls （P＜0.01 for all）. Conclusion Spouse interventions could have remarkable effect in patients′ erectile function, improve treatment satisfaction, enhance self-esteem and sexual relationship satisfaction of patients.