Objective To investigate the effect of a nurse specialist led diabetes management program on diabetes patients. Methods Totally, 1 353 patients with type 2 diabetes were divided into an intervention group of 695 and a control group of 658 according to the order of admission time.The control group was subjected to routine education and followups. The intervention group was assigned to a nurse specialist led diabetes management program and received systematic education and long term followups, with measures including using an App for disease management, and joining a oneday diabetes education & activities subprogram.The effect of the intervention was evaluated after one year. Results The intervention group had more favorable results of fasting plasma glucose, glycated hemoglobin, total cholesterol, and low density lipoprotein than the controls （P＜0.01 for all）. Conclusion The nurse specialist led diabetes management program could have positive impact on diabetes patients′ metabolic indexes.