Objective To investigate the preventive effect of evidence-based standardized nursing intervention on lung infections among elderly bedridden patients. Methods Elderly bedridden patients were selected conveniently from 25 hospitals among 6 provinces and cities in China.The 7 324 cases from November 2015 to June 2016 served as the control group, while 7 323 cases from November 2016 to July 2017 as the intervention group. Routine care was given to the control group, while evidence-based standardized nursing intervention measures including risk assessment, disease observation, preventive measures and health education were given to the intervention group.Results After the confounding factors were controlled, the incidence rate of lung infection in the intervention group was significantly lower than that in the control group (P＜0.01); the implementation rate of standardized nursing intervention measures was 93.98%.Conclusion Standardized preventive nursing intervention can effectively reduce the incidence rate of lung infection in elderly bedridden patients, and nurses′ compliance with the intervention measures is high.