Objective To investigate the intervention effect of group care service provided by medical students on well-being of the disabled elderly in nursing homes. Methods Elderly disabled persons in two public elder care institutions were selected, and randomly divided into an intervention group (n=126) and a control group (n=113) by coin flipping method.The control group was subjected to routine care services, while the intervention group received group care service provided by medical students on the basis of the routine care services in nursing home, once a week, 4 hours each time, for 12 consecutive weeks.Results After intervention, the scores of positive emotion, general positive experience dimension and total well-being score in the intervention group were significantly higher than those in the control group, while the scores of negative emotion and general negative experience dimension in the intervention group were significantly lower than those in the control group (P＜0.01 for all).Conclusion The implementation of group care service provided by medical students for the disabled elderly in nursing homes, can effectively improve physical and mental health of the disabled elderly, and boost their well-being.