Objective To investigate the status of flourishing in patients with diabetic retinopathy （DR）, and to analyze its influencing factors, so as to provide a reference for conducting targeted nursing intervention.Methods From October 2023 to June 2024, convenience sampling method was adopted to select 332 patients with DR from two tertiary-level hospitals, then they were investigated by using a general information questionnaire, the Flourishing Scale, the Herth Hope Index and the Chinese Big Five personality Inventory brief version.Multiple linear regression analysis was conducted to analyze the influencing factors of flourishing in patients with DR.Results The participants′ score of flourishing was （35.72±5.43）.Multivariate linear regression analysis revealed that, marital status, family history of diabetes, number of combined chronic diseases, hope level, neuroticism, rigor, pleasantness and openness of the Big Five personality were the influencing factors of flourishing （all P＜0.05）.Conclusion The flourishing of patients with DR is at a medium and lower level.Medical staff should pay attention to divorced DR patients, those with a family history of diabetes mellitus, suffering from more comorbid chronic diseases, with low level of hope and highly neurotic, and develop psychological intervention strategies to enhance patient′s sense of hope, so as to improve their level of flourishing.