To explore the risk perception experience of cancer in women with high risk human papillomavirus （HPV） infection, so as to provide references for developing targeted early screening programs and intervention strategies.Methods A phenomenological study was designed.Using purposive sampling, 22 high-risk HPV infected women who visited the gynecology outpatient department of a tertiary general hospital were selected and semi-structured interviews were conducted, then the interview data were analyzed using Colaizzi′s seven step analysis method to extract themes.Results Five themes and seventeen subthemes were extracted: cancer risk perception characteristics, cancer risk perception content, perception of health behavior benefits, perception of behavior transition barriers, and perception of risk drivers.Conclusion Medical staff should assist high-risk HPV infected women in establishing correct cancer risk perception, deepening risk awareness education, encouraging family members to actively participate, and improving screening and treatment compliance.