Objective To explore the relationship and interaction mechanism between dyadic coping, stigma and marital quality in female infertile patients and their spouses, so as to provide references for medical staff developing targeted intervention strategies.Methods A total of 235 female infertile patients and their spouses treated in a reproductive center were selected, then they were investigated by utilizing the Dyadic Coping Inventory （DCI）, the Social Impact Scale （SIS） and the Marital Adjustment Test （MAT）.The relationship and interaction of dyadic coping, stigma and marital quality were analyzed by using the Actor-Partner Interdependence Mediation Model.Results The female infertility patients scored higher in stigma, while lower in dyadic coping level and marital quality when compared with their spouses （all P＜0.05）.In the subject effect, the dyadic coping of the dyads had a positive predictive value on their own marital quality, and the stigma of the dyads had a negative predictive value on their own marital quality （all P＜0.05）.In the object effect, the dyadic coping and stigma of the spouse had negative predictive value on the stigma and marital quality of the female infertile patients （all P＜0.05）.The mediating effects showed that, the stigma of the dyads played mediating role between their own dyadic coping and marital quality, and the stigma of the spouse played mediating effect between their own dyadic coping and the marital quality of the female infertile patients （all P＜0.05）.Conclusion There is an interactive mechanism among the dyadic coping, stigma, and marital quality of female infertile patients and their spouses.Healthcare professionals should consider the dyads as a whole, alleviate their stigma, and assist in building a joint coping system to enhance the marital quality of the couple.