Objective To explore the application effect of gamification teaching combined with flipped classroom in burn care tea-ching.Methods A total of 110 undergraduate nursing students enrolled in 2022 were divided into a control group (n=55) and an experimental group (n=55) through a lottery.The control group adopted the traditional teaching model, while the experimental group employed the gamification teaching approach in combination with the flipped classroom teaching model.The theoretical examination scores and after-class assignment scores of the two groups were compared, and the teaching effectiveness was evaluated.Results The theoretical examination scores and after-class assignment scores of the experimental group were significantly higher than those of the control group (all P＜ 0.05); 76.4%-94.6% students in the experimental group recognized the new teaching model and fully affirmed its teaching effect.Conclusion The gamification teaching approach combined with the flipped classroom teaching model can enhance the quality of burn care teaching.Students acknowledge that the teaching model can stimulate their learning motivation, improve their self-directed learning ability, increase their learning participation, and enhance their teamwork ability.