To summarize the nursing experience of a patient in intensive care unit after unilateral lung transplantation assisted by Leonardo Da Vinci robot. The key points of nursing included mechanical ventilation management of transplanted lung;strictly limitation of fluid intake, especially pay attention to controlling the amount of invisible fluid; standard anti-infective and immunosuppressive therapy; early enteral nutrition support and pulmonary function rehabilitation exercise. After being admitted to the ICU for 15 days, the patient was transferred to the general ward and was successfully discharged after 4 days of hospitalization and observation.