Objective To develop a serious game featuring inhalant use guidance for COPD patients, and to evaluate its usability. Methods We developed guidance on inhalants use for COPD patients, and worked with game developers to develop a serious game imbedding inhalant use guidance.Then we selected 30 COPD patients for game experience, and evaluated the usability of the game through observations, interviews and questionnaire survey. Results The serious game had good usability (average usability score >4 points).None of the patients reported game glitches during the first gaming experience, and the average gaming time was 8.73 minutes.Operational errors and requests for help were mainly due to improper input of information interface or insufficient voice/text prompts that led to limited understanding or judgment in patients. Conclusion The serious game featuring inhalant use guidance for COPD patients has good usability and can satisfy patients′ needs of health educations on inhalant use.