Objective To explore the effect of applying Internet plus based out-of-hospital self-management intervention to patients with lower extremity deep vein thrombosis （DVT）. Methods A total of 400 cases of DVT patients who were hospitalized in the department of vascular surgery were randomly divided into 2 groups of 200 cases each.The control group was given routine discharge guidance, while the intervention group was additionally subjected to an Internet plus based self-management intervention program.Twelves months after discharge, the disease-related knowledge level, disease-related self-management behaviors, the recurrence of DVT and the incidence rate of post-thrombosis syndrome （PTS） were compared between the two groups. Results A total of 174 cases in the control group and 189 cases in the intervention group completed the study.The scores of disease-related knowledge and disease-related self-management behavior in the intervention group were significantly higher than those of the control group, and the recurrence rate of DVT and the incidence of PTS were significantly lower in the former than in the latter （all P＜0.05）. Conclusion Internet plus based self-management intervention can improve patients′ knowledge of DVT, promote the formation of disease-related self-management behaviors, reduce the recurrence rate of thrombosis events and incidence of PTS.