Objective To investigate the status quo of self-regulatory fatigue in type 2 diabetes patients, to analyze the influencing factors, and to provide reference for targeted intervention. Methods A total of 242 diabetic patients were surveyed by using the self-regulatory Fatigue Scale, the Fear of Hypoglycemia Scale-15, the Diabetes Distress Scale and the Self-Efficacy for Diabetes. Results The patients scored （45.01±6.81） points in self-regulatory fatigue, （27.98±4.26） points in fear of hypoglycemia, （56.57±10.04） points in diabetes distress, and （24.84±5.42） points in self-efficacy, respectively.Multiple linear regression analysis showed that gender, payment of medical bills, course of disease, treatment plan, disease complications, fasting blood glucose level, fear of hypoglycemia, diabetes distress, and self-efficacy were influencing factors of self-regulatory fatigue （all P＜0.05）. Conclusion Patients with type 2 diabetes have higher levels of self-regulatory fatigue.Clinical nursing workers should pay attention to the influencing factors and formulate targeted intervention measures, in an effort to improve self-regulation level and reduce fatigue level.