Objective To evaluate the current status of core competence of interventional cardiac nurses, to analyze the influencing factors, and to provide references for relevant departments to formulate and improve the training and certification standards of interventional cardiac nurses. Methods Purposive sampling method was used to enroll interventional cardiac nurses, who came from the national cardiovascular nursing and technology training base and its associated hospitals. A self-assessment questionnaire was used to assess the core competence of the nurses. Results The interventional cardiac nurses scored a median of 95.11 （IQR:87.44,98.67） points in core competence.The results of classification tree modelling and ordinal logistic regression analysis showed that out-of-hospital learning experience or advanced training experience in higher level hospital, and work pressure, were associated with core competence of interventional cardiac nurses （all P＜0.05）. Conclusion The overall level of core competence of interventional cardiac nurses is high. In order to further improve nurses′ core competence, nursing managers should pay attention to and reduce the work pressure of nurses, and provide opportunities of learning and advanced training.