Objective To investigate the status and influencing factors of ICU nurses′ knowledge of, attitude towards, and practice of physical restraint, in order to provide reference for continuous quality improvement of physical restraint. Methods Totally, 777 ICU nurses from 15 first-class hospitals in Hubei province were investigated by using the Knowledge-Attitude-Practice（KAP） Questionnaire of Physical Restraint. Results The nurses scored （93.73±6.95） points in knowledge, （70.99±12.59） points in attitude, and （197.47±28.28） points in practice, respectively.Multiple linear regression analysis showed that, age, and education level inf-luenced nurses′ knowledge of physical restraint; the critical care nurse certification, knowledge, attitude and years of working influenced nurses′ practice of physical restraint （all P＜0.05）. Conclusion ICU nurses′ knowledge of physical restraint is at a high level, and their knowledge and practice of physical restraint are influenced by age, education level, years of working, and critical care nurse certification.Nursing managers should formulate and implement targeted training plans for different groups of nurses to further improve the level of physical restraint management.