Objective To explore the effect of implementing decision-aid intervention for decision-making concerning children with acute appendicitis based on Question Prompt List and Personal Decision Guide. Methods A total of 98 guardians of children hospita-lized for acute appendicitis were conveniently selected as the research objects, and were divided into the control group and the intervention group according to the hospitalization period, with 49 cases in each group.The guardians in the control group were given routine preoperative conversation and health education, while those in the intervention group were additionally given decision-aid intervention developed based on Question Prompt List and Personal Decision Guide.The differences in scores of decisional conflict, decision-making preparation and satisfaction with decision-making participation were compared between the two groups. Results After the intervention, the decisional conflict score of the guardians in the intervention group was significantly lower than that in the control group; the decision-making preparation score and the satisfaction score of decision-making participation were significantly higher in the former than those in the latter （all P＜0.05）. Conclusion Decision-aid intervention based on Question Prompt List and Personal Decision Guide can reduce decisional conflict of guardians of children with acute appendicitis, and improve their decision-making preparation and satisfaction with decision-making participation.