Objective To explore psychological adjustment experience of patients developing prostate-specific antigen test （PSA） an-xiety after radical prostatectomy for prostate cancer, and to provide a basis for the development of targeted intervention strategies. Methods A descriptive phenomenological research method was used to conduct semi-structured in-depth interviews with 12 patients developing PSA anxiety after radical prostatectomy for prostate cancer, who were selected through purposive sampling.The interview data were collated and analyzed using Collaizzi′s 7-step analytical method. Results The essence of psychological adjustment experience in patients developing PSA anxiety after radical prostatectomy for prostate cancer was returning to normalcy, which consisted of 3 themes branching into 8 sub-themes, including emotional adjustment （intermittent fear, cyclical anxiety, gaining a sense of control）, cognitive adjustment （change in disease perception, increased need awareness） and behavioral adjustment （avoidance and masking, healthier lifestyles, participation in social activities）. Conclusion Patients developing PSA anxiety after radical prostatectomy for prostate cancer strive to return to normal life through psychological adjustment in three aspects of emotion, cognition, and behavior.In the future, healthcare professionals should pay attention to the changes in patients′ emotion needs at different stages, and guide and promote patients′ positive emotional, cognitive, and behavioral adjustment.