Objective To determine the current situation and factors associated with continuous positive airway pressure ventilation (CPAP) compliance in post-stroke patients with obstructive sleep apnea in community. Methods In this cross-sectional study, 141 post-stroke patients with obstructive sleep apnea were recruited in sleep center by convenient sampling. All eligible participants accessed the demographic data, clinical symptoms, sleep quality, and health belief at baseline, and CPAP compliance at 6-month follow-up. Results The CPAP compliance rate among studied population was 29.8%. Logistic regression revealed that higher income level, more serious stroke injury, and higher total score of health belief were protective factors（P<0.05 for all）. Conclusion CPAP compliance in post-stroke patients is low in the domestic community. Health provider should enforce the health education to promote the health beliefs of disease, and increase the awareness of mild patients with stroke to improve the patient′s compliance.