Objective In this study, we aim to explore the impact of family based intervention on cognitive function and quality of life in Alzheimer's disease patients in order to promote patients to return home. Methods A total of 64 patients were divided into two groups according to their district, with 32 patients in each group. The control group received routine psychiatric care, while the observation group received home based intervention based on occupational therapy, using a combination of online and offline intervention methods. We evaluated the scores of the Montreal Cognitive Assessment Scale, the Instrumental Activities of Daily Living Scale, and the Quality of Life-Alzheimer′s Diseas before and 6 months after the intervention. Results Thirty patients from each group completed the study. The scores of Montreal Cognitive Assessment Scale, Instrumental Activities of Daily Living Scale and Quality of Life-Alzheimer′s Diseas in the observation group 6 months after intervention were significantly higher than those in the control group (all P<0.05). Conclusion Family regression intervention can significantly improve the cognitive function of patients with Alzheimer′s disease, and improve instrumental activities of daily living and quality of life.