Objective To investigate the current situation and influencing factors of thriving at work among nurses, so as to provide reference for formulating effective intervention measures. Methods A total of 269 nurses in 4 grade A hospitals in Hefei city were selected by convenience sampling methods. They were surveyed with a demographic questionnaire, the Thriving at Work Scale, the Psychological Capital Scale, the Job Crafting Questionnaire, and the Superior Developmental Feedback Scale. Results The nurses scored (51.65±10.24) points in thriving at work, which was positively correlated with the total score of psychological capital, job crafting, and developmental feedback from superiors (all P＜0.05). Developmental feedback from superiors could directly affect thriving at work （β=0.287）, or indirectly affect the thriving at work through job crafting and psychological capital （indirect effects accounting for 61.32% of the total effect）. Conclusion Nurses′ thriving at work is at a medium level. Hospital managers can consider promoting developmental feedback from superiors, and improving nurses′ job crafting and psychological capital to uplift nurses′ thriving at work.