Objective To evaluate the influence of different interface of non-invasive ventilation equipment on nasal pressure injury in children in NICU by using network meta-analysis. Methods Chinese and English databases were searched comprehensively for non-invasive ventilation through different connection interfaces. The search period was from database construction to March 2023. Literature was screened according to inclusion and exclusion criteria, and quality evaluation and data extraction were carried out. StataSE14.0 software was used to conduct network meta-analysis. Results A total of 24 literatures were included, involving 7 non-invasive ventilation connections including nasal prongs, nasal mask, nasal cannula, rotation use of nasal prongs and nasal mask, helmet, long and narrow tubing, and short binasal prongs and mask. The results of network meta-analysis showed that the probability of nasal pressure injury from small to large was helmet, nasal cannula, nasal mask, rotation use of nasal prongs and nasal mask, and nasal prongs. Reducing the incidence of Grade Ⅲ nasal stress injury ranked first as rotation nasal prongs and nasal mask. Conclusion The helmet has a larger confidence interval and is less reliable than other connection methods. Nasal cannula is recommended as the best interface for non-invasive ventilation in children in NICU. Rotation use of nasal prongs and nasal mask can reduce the occurrence of nasal stress injury of Grade Ⅲ, which can be selected according to the actual situation of the hospital.