Objective To explore the application effect of hospital discharge preparation service based on timely mode in patients with oral cancer, in order to improve their discharge readiness and quality of life. Methods Patients who underwent oral cancer skin flap transplantation were divided into 89 cases in a control group （85 completed studies） according to the date of admission. Routine nursing and discharge guidance were given to oral and maxillofacial surgery. In the intervention group of 89 patients, a multidisciplinary team was established to develop the discharge preparation service process based on "Timing It Right" framework, and responsible nurses implemented discharge preparation service according to the needs of patients at different stages of perioperative period. Results There were statistically significant differences in discharge readiness, discharge guidance quality and life quality scores of oral cancer patients between the two groups (all P＜0.05). Conclusion The "Timing It Right" framework based discharge preparation service can improve the level of discharge readiness of patients with oral cancer, improve the quality of discharge guidance, and improve the postoperative quality of life of patients.