Objective To investigate the status quo of discharge destination among stroke patients and analyze its influencing factors, so as to provide reference for targeted interventions. Methods A questionnaire survey was conducted on 371 stroke patients in neurology department. The questionnaires included the F RAIL Scale, Social Support Rating Scale, the Hospital Anxiety and Depression Scale, and a general information questionnaire designed based on the ecological model of health. The influencing factors were analyzed based on whether there was a change in discharge destination. Results Of the participants, 136 (36.7%) experienced change in discharge destination. Logistic regression analysis showed that pre-stroke frailty, moderate stroke severity, severe ADL dependency level, depressive symptoms, living alone or with a spouse, cognitive impairment, and moderate-to-high risk of falls were risk factors for change in discharge destination (all P<0.05). Conclusion The incidence of discharge destination change is relatively high among stroke patients. Medical staff should conduct assessment and screening in the early stage of hospitalization, focus on risk factors, provide early intervention, and assist patients to transit smoothly to appropriate post-discharge residence.