Objective To summarize the best evidence for care of cutaneous graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation in children, and to provide guidance for clinical care. Methods BMJ Best Practice, UpToDate, the Joanna Briggs Institute Evidence-Based Practice Database, Nursing Professional Committee of Chinese Anti-Cancer Association, PubMed, CNKI, WanFang data and other databases were searched from January 1, 2000 to May 31, 2023. Results A total of 17 publications were eligible (3 clinical decision recommendations statements, 7 guidelines, 1 systematic review, 4 expert consensus reports and 2 evidence summaries), and 24 pieces of best evidence were summarized in 5 aspects: skin assessment, skin protection, management of adverse skin reactions, medication guidance, follow-up and screening. Conclusion The best evidence for the care of cutaneous GVHD after hematopoietic stem cell transplantation in children can be used as a guidance for clinical care.