This paper presents an overview of the common problems regarding medication, current status of safe medication use, evaluation tools and safeguard measures for patients with chronic diseases during the hospital-home transitional period.It is also suggested that health care system should attach great importance to older adults′ safe medication use during hospital-home transitional period, and multidisciplinary teamwork should be further strengthened to optimize the management process of safe medicatio use.Meanwhile, health care system should implement drug auditing and optimization, mobilize patients′ self-management of medication, and establish an electronic sharing platform with a view to achieving safe medication use for elderly patients with chronic diseases in the hospital-home transition period.