Objective To explore the prevalence and influencing factors of medication discrepancy during hospital-to-home transition period in patients with ischemic stroke(IS). Methods Respectively, 190 IS patients who had been returning home from hospital stay for 2 weeks and another 190 ones for 8 weeks were selected.Through telephone follow-ups, the Medication Discrepancy Tool was used to assess medication discrepancy in the samples.Influencing factors of medication discrepancy were explored. Results The pre-valence of medication discrepancy in the home-for-8-week sample (65.26%) was higher than that in the home-for-2-week sample (56.32%).The main types of medication discrepancies were reduced types of drugs (42.94%,54.87%) in the 2 samples.In the home-for-2-week sample, cardio-cerebrovascular drugs were the main type of drugs contributive to discrepancies, with "forgetting" (22.70%) and "not prescribing drugs in time after taking them" (16.56%) being the most cited reasons.In the home-for-8-week sample, cardio-cerebrovascular drugs were the main type of drugs contributive to discrepancies, with "adding or decreasing drugs for symptom improvement" (22.12%) and "forgetting" (16.37%) being the most cited reasons.The results of logistic regression analysis showed that higher number of diagnosed diseases at discharge was risk factor for medication discrepancy in the home-for-2-week sample (P＜0.05), while relatively younger age and higher number of prescription drugs were risk factors for medication discrepancy in the home-for-8-week sample (all P＜0.05). Conclusion The prevalence of medication discrepancy is high in IS patients during hospital-to-home transition period, and the influencing factors of medication discrepancy vary in patients with diffe-rent lengths of home stay since hospital discharge.Effective measures targeting the influencing factors of medication discrepancy at different stages, should be actively explored, in an effort to ensure patient medication safety during the transition period.