Objective To explore an effective method for symptom management during home based immunotherapy for cancer patients. MethodsA total of 132 cancer patients undergoing immunotherapy were randomly divided into two groups: the control group (n=66) and the intervention group (n=66). The control group received routine health education and nursing care, while the intervention group additionally used a self reported outcome manual for reporting immune related adverse events (irAEs). After a 6 month intervention period, the reporting accuracy, timing of reporting, severity of irAEs, symptom burden, and quality of life were compared between the two groups. ResultsAmong the participants, 62 in the control group and 63 in the intervention group completed the entire study. The intervention group showed significantly higher accuracy in reporting irAEs, shorter reporting time, milder symptom burden, and higher quality of life compared with the control group (all P<0.05). ConclusionThe use of a self reported outcome manual can help patients identify irAEs, improve the accuracy and timeliness of reporting, reduce symptom burden, and enhance their overall quality of life.