Objective To cultivate nurses with the ability to perform midline catheter insertion at the institutional level and improve the quality of intravenous therapy.MethodsA training program for nurses on midline catheter insertion was developed based on the Miller′s Pyramid model.ResultsA total of 48 nurses received the training, of whom 31 nurses successfully passed the certification examination, resulting in a pass rate of 64.58%. Nurses performed 1,736 cases of midline catheter insertion, with the success rate of 96.34%. None of patients who had midline catheters developed complications related to catheter insertion. ConclusionThe training program for nurses on midline catheter insertion developed based on the Miller′s Pyramid model, can standardize midline catheter insertion and enhance the quality of intravenous therapy.