Objective To develop a specific nursing shift handover system for the delivery room and to improve the quality of nurse shift handover.MethodsBased on ISBAR handoff format, a computerized nursing handover system was constructed for the delivery room. Time to documenting handover report, the number of errors and omissions in the handover report, midwives′ evaluation of the handover quality and their general self efficacy were compared before and after application of the system by investigating 62 midwives who used the handover system. ResultsAfter application of the handover system, time to documenting handover report was significantly reduced (P<0.05), and the number of errors and omissions in the handover report decreased. Midwives′ evaluation of the handover quality and their general self efficacy were significantly improved (both P<0.05). ConclusionThe computerized nursing shift handover system based on ISBAR handoff format for the delivery room can standardize midwives′ shift handover behavior, reduce documentation time and errors in the report, and improve the quality of handover and midwives′ general self efficacy.