Objective To explore the effect of combined compression hemostasis device in promoting vascular hemostasis following percutaneous coronary intervention (PCI) via the brachial artery approach. MethodsSixty patients who underwent PCI using the brachial approach were divided into two groups, with 30 patients in each group. The control group was given conventional compression using 3M elastic bandage, while the intervention group used the combined compression hemostasis device. Incidence of bleeding, local swelling degree and pain were compared between the two groups immediately and at 2, 4, and 6 hours after the procedure. The occurrence of pressure injury at the compression site was also observed for 24 hours. ResultsCompared with the control group, the intervention group had significantly milder local swelling and pain at different time points, and also significantly lower incidence of bleeding and pressure injury (all P<0.05). ConclusionThe combined compression hemostasis device achieved better vascular hemostasis and was safe for operation, resulting in significant reductions in pain and pressure injuries.