Objective To develop a non pharmacological management protocol for patients with advanced cancer experiencing respiratory distress symptoms, aiming to relieve their dyspnea. MethodsGuided by symptom management theory, a literature review and semi structured interviews were conducted to create an initial version of the management protocol. The draft protocol was then revised and refined through expert group meetings. ResultsThe management protocol included three main sections:assessment of respiratory distress symptoms, management strategies, and outcome evaluation; and the protocol also focused on dyspnea before, during, and after the onset. ConclusionThis protocol developed by an evidence based approach and by considering both patient and expert stakeholder opinions, has good reliability and feasibility. It can provide reference for alleviating respiratory distress symptoms in patients with advanced cancer.