Objective To reduce the complications caused by nasal frenulum fixation in premature infants with nasal continuous positive airway pressure ventilation. Methods A total of 136 premature infants who met the inclusion criteria were randomly divided into two groups.The intervention group （67 cases） received the improved lacing method, and the control group （69 cases） received the film tense-free wrapping cotton ball and lacing method.The occurrence of eye swelling, upturned nose, nose skin damage, duration of continuous positive airway pressure ventilation and length of hospital stay were compared between the two groups. Results The incidence of eye swelling, upturned nose and nasal skin damage in the intervention group was significantly lower than that in the control group, and the duration of continuous positive airway pressure ventilation and the length of hospital stay were significantly shorter than those in the control group （all P＜0.05）. Conclusion The modified nasal frenulum fixation method can effectively fix the location of nasal congestion, ensure effective ventilation time, reduce the incidence of related complications, and shorten the length of hospital stay for premature infants.