Objective To explore the effect of sterilized traditional Chinese medicine (TCM) application on preventing needle tract infections in patients with fracture undergoing external fixation. Methods A total of 47 patients with fracture treated with temporary external fixation were randomly divided into an experimental group (24 cases) and a control group (23 cases).In the experimental group, sterile TCM application was applied to the needle tract and replaced once every 7 days.In the control group, sterilized gauze was used to cover the needle track, and the gauze was soaked with 75% ethanol twice a day, and the gauze was changed every 3 days.The needle tract infection rate, needle tract pain, and adverse events were compared between the two groups.The white blood cell count (WBC) and C-reactive protein (CRP) were also detected to evaluate the effect. Results The needle tract infection rate was 4.17% in the experimental group and 26.09% in the control group, with a statistically significant difference (P＜0.05).The local pain degree of the experimental group was significantly lower than that of the control group from the 3rd to 7th day after intervention (all P＜0.05).On the 7th day after intervention, the value of CRP in the two groups was significantly different (P＜0.05).No adverse events occurred in the experimental group, and 2 cases of skin allergy around the needle tract occurred in the control group, and no serious adverse events occurred. Conclusion The TCM application in the nursing of external fixation needle track can effectively prevent infections and reduce patient pain.The effect of TCM application in this context is significant.