Objective To investigate the trend of changes in spouse′s couple disease communication and enterostomy patients′ perceived social constraints within sixth months after discharge, and to analyze the causal relationship between these two variables. Methods A total of 206 enterostomy patients and their spouses were investigated with the general information questionnaire, Social Constraints Scale, and Cancer-related Communication Problems within Couples Scale at 1 month, 3 months and 6 months after discharge. Results Within 6 months after discharge, the perceived social constraints of patients with enterostomy and their spouse′s couple disease communication showed an improvement trend (both P＜0.05).The cross-lag model revealed that the spouse′s couple disease communication at 1 month after discharge could affect the patients′ perceived social constraints at 3 months after discharge (β=0.254,P＜0.05), and the spouse′s couple disease communication at 3 months after discharge could also affect the patients′ perceived social constraints at 6 months after discharge (β=0.153,P＜0.05)).However, the enterostomy patients′ perceived social constraints had no predictive effect on spouse′s couple disease communication (all P＞0.05). Conclusion The perceived social constraints of patients with enterostomy and their spouse′s couple disease communication gradually improve after discharge, and spouse′s couple disease communication can predict patients′ perceived social constraints.Medical staff should timely assess the communication status between patients and their spouses and promote healthy communication between them so as to alleviate patients′ perceived social constraints.